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Clindamycin is an antibiotic that fights bacteria in the body.Clindamycin is used to treat serious infections caused by bacteria.
Active Ingredient: Сlindamycin, Hydrochloride
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What is Clindamycin used for
Clindamycin is a broad-spectrum antibiotic produced in various dosage forms for the treatment of infectious diseases. Widely used in pediatrics.
The active ingredient has a bacteriostatic effect when used in therapeutic doses, and in high doses – a bactericidal effect on strains sensitive to Clindamycin. Clindamycin is widely used, including in pediatrics, in various diseases of the respiratory tract, soft tissues, joints and bones caused by:
- Corynebacterium diphtheriae;
- Peptococcus; Clostrtidium tetani;
- Clostrtidium perfringens;
- Staphylococcus spp .;
- Fusobacterium spp. (with the exception of F.varium, which is resistant);
- Streptococcus spp .;
- Bacteroides spp;
- Bacillus anthracis;
- Peptostreptococcus spp ..
According to the instructions for Clindamycin, most gram-negative aerobic bacteria are resistant, resistant strains of Staphylococcus aureus, Neisseria gonorrhoeae, Haemophilus influenzae and Neisseria meningitidis, as well as viruses and fungi (including yeast).
Сlindamycin vs Amoxicillin
According to statistics, the total share of antibiotic prescriptions worldwide is about 40%. That is, compared with other drugs, these drugs are used much more often. Of the total mass of such drugs, penicillin or tetracycline agents are most often used. For example, such as Amoxicillin or Clindamycin. Therefore, it is not surprising that most patients want to know what the difference between them is and are they considered good?
So, what is better than Clindamycin or Amoxicillin? What are the main differences of one drug from another? When and why are they prescribed? It happens that patients consider these antibiotics counterparts because of similar indications. However, this is not the case.
Of course, the main difference lies in the mechanism of action of drugs. After all, Clindamycin is a bacteriostatic antibiotic, and Amoxicillin is bactericidal. It would seem, while comparing these drugs is simply impossible. However, they have similarities.
The main mechanism of action is the suppression of the synthesis of the protein of bacteria that provoke the development of infection. The bacterium itself does not die, but loses its ability to reproduce its own kind.
Due to this effect, Clindamycin is especially effective for rapidly spreading infections. In addition, it is able to penetrate into the infected cell. Therefore, this drug acts in many intracellular infections, for example, with chlamydia.
The drug is available in capsules for oral administration. In the blood from the stomach enters quickly enough, and the maximum effect reaches within two hours. Another property Clindamycin – the ability to accumulate in the body, mainly in the teeth and bones. It can also get into all organs and tissues with the exception of cerebrospinal fluid. Penetrates through the placenta, as well as accumulates in breast milk.
Semisynthetic antibiotic, which is included in the penicillin class. According to the classification, Amoxicillin is a drug with a bactericidal effect, that is, it causes the death of a pathogenic microorganism.
The main mechanism of action is a violation of the synthesis of specific proteins that make up the protective, peptidoglycan layer in the membranes of bacteria. The result of this influence is the inability of the shell to withstand the differences in internal and external pressure. Because of this, the microorganism simply swells and breaks.
Amoxicillin is produced not only in tablets, but also in the form of a suspension for children and an injection. After entering the body, it is quickly distributed to all organs and tissues. Penetrates through the placenta and partially through the blood-brain barrier, that is, enters the brain tissue.
The dose of Clindamycin and the choice of its dosage form depend on the disease, the course of the disease and age.
For severe infections and diseases of the abdominal cavity, Clindamycin is used as an injection according to the instructions. In milder forms, 1.2-1.8 g are usually administered per day, and in severe forms, 2.4-2.7 g are divided into 2-4 doses. Simultaneously should not be administered more than 600 mg of Clindamycin.
Intravenous drip Clindamycin used in inflammation of the uterus and peritoneum, which is localized in the pelvic area, every 8 hours at 0.9 g. Intravenous Clindamycin is used for at least four days and then at least two days after the onset of improvement.
Clindamycin tablets are used after reaching the clinical effect, every 6 hours, 450 mg to complete a two-week course of therapy.
Clindamycin tablets are also used to treat mild to moderate infectious and inflammatory diseases. Adults are prescribed every 6 hours for 150-450 mg for at least 10 days.
Clindamycin pediatric dose
In pediatrics, Clindamycin is most often used as a syrup, for which 60 ml of water is added to a bottle of granules. The dose of the drug is calculated based on body weight and age of the child. The daily dose for children from a month is 8-25 mg per 1 kg of body weight, divided into 3-4 doses. For children weighing up to 10 kg or less, a half-spoon is prescribed three times a day. Clindamycin tablets can be used from 8 years old with a weight of at least 25 kg.
Clindamycin is rarely prescribed for pregnant women. Through the placenta, it easily penetrates to the fetus both at an early stage and at a late stage of pregnancy. The drug accumulates in the internal organs of the fetus, but to date its effect on the fetus has not been studied sufficiently, therefore, it is prescribed during pregnancy in extreme cases and under the strict supervision of specialists.
The most used antibiotics for pregnant women are drugs of the penicillin group. Unlike clindamycin, penicillins are widely studied and have no toxic effect on the developing fetus. Cephalosporins can also be prescribed for pregnant women, regardless of the duration of pregnancy.
Unlike clindamycin and penicillin, the administration of tetracyclines for the treatment of pregnant women is absolutely contraindicated. When taking tetracyclines, the fetus develops various pathologies, for example, arresting bone growth. Therefore, drugs of this group cannot be prescribed for pregnant women.
Before use, you should consult with a specialist.
Clindamycin side effects
Clindamycin causes various side effects.
After intravenous administration, metallic taste, phlebitis, abscess may appear. After taking Clindamycin tablets – phenomena of esophagitis, abdominal pain, diarrhea, liver disease and jaundice.
Rarely can occur urticaria, reversible leukopenia, fever, angioedema, neutropenia, thrombocytopenia, agranulocytosis, low blood pressure, weakness.