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Bactrim is a synthetic antibacterial product used to treat ear infections, acute exacerbations of chronic bronchitis, urinary tract infections.

Active Ingredient: Trimethoprim, Sulfamethoxazole

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What is Bactrim used for

Bactrim is a combined antimicrobial drug whose main active ingredients are sulfamethoxazole and trimethoprim.

Available in the form of tablets, infusion solution and syrup. There is also a Bactrim suspension for internal administration.

It has extensive antibacterial and bactericidal action. The effect of the drug is based on the inhibition of biosynthesis and the process of activation of folic acid in the cells of microorganisms, which blocks the metabolism of bacteria. The drug effectively fights intestinal, hemophilic, pertussis bacilli, pathogens of intestinal yersiniosis, tularemia, nocardiosis, coccidioidosis, legionellosis and pneumocystis pneumonia.

Shows activity in relation to staphylococci, streptococci, meningococci, gonococci, salutinists, and listeria, fecal enterococci, brucella, shigella, chlamydia, cholera vibrioes, klebsiella, citrobacter, enterobacter, plasmodium, morganelum, chlamydia, cholera vibrioes, klebsiella, citrobacter, enterobacter, plasmodium, morganelum, chlamydia, cholera vibrioes, klebsiella, citrobacter, enterobacter, plasmodium, morganelum, chlamydia, cholera vibrioes, klebsiella, citrobacter, enterobacter, plasmodium, morganel, and chlamydia;

Used to treat:

  • Respiratory tract infections: chronic and acute bronchitis, exacerbation of chronic bronchitis, pneumocystis and lobar pneumonia, bronchopneumonia, bronchiectasis.
  • Gastrointestinal infections: cholera, typhoid fever and paratyphoid fever, cholangitis, gastroenteritis, cholecystitis, dysentery, salmonello carrier.
  • Urogenital infections: gonococcal urethritis, soft chancre, cystitis, inguinal granuloma, pyelonephritis, gonorrhea, pyelitis, prostatitis, epididymitis, venereal lymphogranuloma.
  • Infections of the skin: acne, pyoderma, furunculosis, wound infections.
  • Infections of upper respiratory tract: tonsillitis, scarlet fever, laryngitis, sinusitis, otitis media.
  • Other bacterial infections caused by a number of microorganisms: osteoarticular infections, brucellosis, toxoplasmosis, nocardiosis, acute and chronic osteomyelitis, actinomycetomas, South American blastomycosis, malaria.

Bactrim in pregnancy

Is it possible to use Bactrim during pregnancy? Experiments that were conducted on animals suggest that large doses of the drug can lead to fetal malformations. This is a typical condition in case of folic acid deficiency.

According to the survey data, there were no individual reports of fetal defects in women. Taking the medicine seems to have nothing to do with a significant risk of human teratogenicity. Indeed, TMP and SMZ are able to penetrate the placental barrier. Thus, they can affect the metabolism of folic acid, which occurs during pregnancy.

The drug is prescribed only in those cases where the expected benefit from its use may exceed the risk to the fetus. Pregnant women who are recommended to take this medicine are prescribed 5-10 mg of folic acid supplement.

It is forbidden to use the product in the later periods. There is a risk of developing nuclear jaundice in newborns. TMP and SMZ can penetrate into breast milk. Therefore, during the period of feeding the child, to take the tool in any case can not. Bactrim can be used only with the permission of the doctor.

How long does Bactrim stay in your system

The therapeutic effect of the drug lasts seven hours. For acute infectious diseases, syrup, tablets and Bactrim suspension should be taken for at least five days until the patient shows no symptoms of infection. If improvement does not occur after seven days, the patient’s condition must be re-evaluated for possible correction of therapy.

Bactrim dosage

Adults and children over 12 years old – 960 mg once, or 480 mg 2 times a day. For severe infections, 480 mg 3 times a day, for chronic infections, a maintenance dose is 480 mg 2 times a day. Children 1-2 years old – 120 mg 2 times a day, 2-6 years – 120-240 mg 2 times a day, 6-12 years – 240-480 mg 2 times a day.

Bactrim side effects

Side effects can occur in the urinary system (impaired renal function, interstitial nephritis, hematuria, toxic nephropathy, oliguria, anuria, polyuria, hypercreatininemia, crystallology, an increase in urea concentration), musculoskeletal (arthralgia, myalgia) and respiratory system (bronchospasm pulmonary infiltrates).

Reception can cause the development of neutropenia, megaloblastic anemia, agranulocytosis, leukopenia, thrombocytopenia, pseudomembrane enterocolitis, gastritis, hepatonecrosis, hepatitis, cholestasis, glossitis, stomatitis, hypoglycemia, allergic manifestations.

Taking Bactrim can cause an increase in liver transaminase activity, abdominal pain, loss of appetite, nausea, diarrhea and nervous disorders (headaches, dizziness, in rare cases – depression, aseptic meningitis, tremor, apathy, peripheral nephritis).

Bactrim interactions

This drug has interactions with other drugs, but it is done with extreme caution. The pharmaceutical agent is compatible with levulose, sodium chloride, dextran, dextrose and Ringer’s solution.

The drug is able to increase the anticoagulant activity of indirect anticoagulants. In addition, it increases the effect of hypoglycemic drugs and methotrexate. The intensity of hepatic metabolism of phenytoin and warfarin is significantly reduced. Their overall effect is increasing.

Perhaps a decrease in the reliability of oral contraception. This is because under the influence of the drug, the intestinal microflora is inhibited and the enterohepatic circulation of hormonal compounds is reduced.

If you take the drug together with pyrimethamine in high doses, it can trigger the development of megaloblastic anemia. Diuretics can increase the risk of thrombocytopenia. Significantly reduced effect of taking procain, procainamide and benzocaine. Phenytoin can cause a manifestation of folic acid deficiency.

Derivatives of salicylic acid can enhance the effect of the drug. Kolestiramin reduces absorption, so it is recommended to take it an hour after co-trimoxazole. Using Bactrim, it is worth considering all of the above and consult with your doctor.