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Erythromycin is used to treat many different types of infections caused by bacteria. Active Ingredient:

Active Ingredient:

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What is Erythromycin?

Erythromycin is an antibacterial drug belonging to the macrolide group. Designed for system use. Available in the form of a lyophilisate for intravenous administration, tablets and ointment for external use.

Pharmacological action of erythromycin

The active active ingredient of the drug in all forms of release is erythromycin.

The drug has bacteriostatic properties. In high doses, Erythromycin according to the instructions has a bactericidal effect on many sensitive microorganisms.

The drug reversibly binds to the ribosomes of bacteria, thereby blunting protein synthesis.

When used, Erythromycin is active against many gram-positive (Staphylococcus spp. And more), Gram-negative (Corynebacterium diphtheriae, Legionella spp., Brucella spp., Bacillus anthracis, Bordetella pertussis, Haemophilus, and Bacillus anthracis, Bordetella pertussis, Haemophiluschrophyses, Bacillus anthracis, Bordetella pertussis, Haemophilus, and Bacillus anthracis. spp.) bacteria.

Erythromycin treatment is also effective for diseases caused by Rickettsia spp., Spirochaetaceae, Chlamydia spp., Mycoplasma spp.

Gram-negative bacilli, such as Salmonella spp., Pseudomonas aeruginosa, Shigella spp., Escherichia coli, are resistant to the drug.

When using Erythromycin is its uneven distribution in the body. The main part of the substance accumulates in the liver, spleen and kidneys. The drug penetrates perfectly into ascitic and synovial fluids, into the lung tissue, the pleural cavity and sperm. In small concentrations, erythromycin is stored in the cerebrospinal fluid. Metabolized in the liver, excreted in large part with bile. The period of complete elimination from the body is 3-4 hours.

Indications for use of Erythromycin

Treatment with Erythromycin is prescribed for infectious diseases caused by microorganisms sensitive to it, such as:

  • Syphilis;
  • Gonorrhea; Cholecystitis;
  • Listeriosis;
  • Amoebic dysentery;
  • Scarlet fever;
  • Prostatitis;
  • Diphtheria.

In accordance with the instructions, Erythromycin is effective for lesions of the mucous membrane of the eyes, including in newborns, as well as inflammation of the organs of the urogenital system in pregnant women.

The antibiotic is used to prevent the development of infectious complications during various therapeutic and diagnostic procedures.

Erythromycin Uses and Dosages

Erythromycin tablets are taken orally, without chewing. Daily dosage of medication for adults is 1-2 g, one-time – not more than 0.5 g. If necessary, it is possible to increase the daily dosage to 4 g. The interval between doses is at least 6 hours.

For children from 4 months to 18 years, the dosage of the drug is prescribed depending on the severity of the disease, age and body weight of the child, based on the dose of 0.03-0.05 g / kg per day, divided into 2-4 doses. Children under 4 months are recommended at 0.02-0.04 g / kg per day. Possible doubling of the dose according to the testimony of the attending physician.

When diphtheria take 0.25 g of erythromycin per day.

When legionellosis take 0.5-1 g of the drug 4 times a day for 2 weeks.

In the treatment of amoebic dysentery, a single dose of the drug for adults is 0.25 g (multiplicity 4 times a day), the daily dosage for children is 0.03-0.05 g per 1 kg of weight. The course of treatment is 10-15 days.

To prevent infectious complications, 1 g of erythromycin is recommended for 19, 18 and 9 hours before the operation.

For infections of the urogenital system in pregnant women take 0.5 g 4 times a day for 1 week.

For the treatment of eye diseases, Erythromycin ointment is placed in the lower eyelid.

For skin lesions, lubricate the affected areas with a solution for external use.

Side Effects of Erythromycin

In the reviews of Erythromycin, it was noted that the drug can cause allergic reactions in the form of pruritus, rash, burning and swelling. With prolonged treatment with erythromycin, jaundice, nausea, diarrhea, vomiting, and the development of resistance to it by pathogenic organisms are possible.

Contraindications to the use of Erythromycin

According to the instructions, Erythromycin and analogues are not prescribed during pregnancy, breastfeeding, concomitant use with Astemizol or Terfenadine, with liver failure.

Erythromycin overdose

In case of an overdose of Erythromycin, according to reviews, hearing loss and acute liver failure are observed. Symptomatic treatment.